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Table 5 Treatment of mannitol or corticosteroids before or after the administration of alectinib

From: Intracranial efficacy of alectinib in ALK-positive NSCLC patients with CNS metastases—a multicenter retrospective study

Patients with CNS-related symptoms in the baseline, n = 28

Before the initiation of alectinib

After the treatment of alectinib

Number of patients who needed mannitol or corticosteroids

18 (64.3%)

3 (10.7%)

Number of patients who didn't need mannitol or corticosteroids

10 (35.7%)

25(89.3%)

  1. Fisher exact test: p < 0.001, the number of patients who were in need of mannitol or corticosteroids decreased remarkably after the treatment of alectinib