Table 8 Characteristics of patients with LM before the treatment of alectinib, n = 9
Evidence of LM diagnosis | Symptoms + MRI + CSF, n = 1 Symptoms + MRI, n = 7 MRI, n = 1 |
|---|---|
Accompanied with BM | n = 5 |
Previous history of ALK-TKI | ALK-TKI naive, n = 4 Crizotinib-resistant, n = 2 Other second generation ALK-TKIs, n = 3 |
Uncontrolled CNS metastases | n = 9 |
CNS-related symptoms | n = 8 |
ECOG | |
0–1 ≥ 2 | n = 1 n = 8 |
Number of patients needed mannitol or corticosteroids | n = 7 |