Table 1 Change in LDL-C from baseline to end of treatment

Baseline (mmol/L), mean (SD)

3.360

(0.928)

3.656

(0.951)

3.563

(0.900)

3.464

(0.753)

3.759

(0.874)

3.608

(0.674)

3.420

(0.835)

 LS mean (95% CI)

4.44

(−3.69, 12.57)

−48.63

(−59.80, −37.46)

−55.06

(−62.96, −47.17)

−52.02

(−63.12, −40.86)

−48.38

(−56.32, −40.44)

−43.93

(−55.10, −32.77)

−52.77

(−60.49, −45.05)

 Change relative to placebo, LS mean (95% CI); p

..

−53.07

(−66.91, −39.23);

p<0.0001

−59.51

(−70.84, −48.17);

p<0.0001

−56.46

(−70.26, −42.67);

p<0.0001

−52.82

(−64.24, −41.40);

p<0.0001

−48.37

(−62.20, −34.55);

p<0.0001

−57.21

(−68.39, −46.04);

p<0.0001

 LS mean (95% CI)

0.02

(−0.27, 0.31)

−1.69

(−2.09, −1.29)

−1.9

(−2.18, −1.62)

−1.84

(−2.24, −1.44)

−1.73

(−2.01, −1.44)

−1.57

(−1.98, −1.17)

−1.85

(−2.13, −1.58)

 Change relative to placebo, LS mean (95% CI); p

..

−1.71

(−2.21, −1.22);

p<0.0001

−1.92

(−2.33, −1.51);

p<0.0001

−1.86

(−2.36, −1.37);

p<0.0001

−1.75

(−2.16, −1.34);

p<0.0001

−1.59

(−2.09, −1.10);

p<0.0001

−1.87

(−2.28, −1.47);

p<0.0001