Fig. 5

Clinical outcomes according to vaginal microbial composition in sporadic miscarriage. Increased Lactobacillus spp. depleted vaginal microbial communities were observed in sporadic euploid miscarriages (n = 39) compared to sporadic aneuploid miscarriages (n = 28, P = 0.02 two-tailed Fisher’s exact test) and viable term pregnancies (n = 70 P = 0.05 two-tailed Fisher’s exact test, a). No significant difference was seen between euploid (n = 15) and aneuploid (n = 11) miscarriages in the recurrent miscarriage group (b). A significantly increased prevalence of non-Gardnerella vaginal bacterial communities was seen in euploid miscarriages compared to aneuploid miscarriage, P = 0.03 and viable pregnancy P = 0.04 (two-tailed Fisher’s exact test, c). Differentially abundant taxa identified by LDA in euploid miscarriage compared to viable pregnancy are shown in e. Data represented as percentages in a, b, c and d. LEfSe analysis (e) depicting particular vaginal bacterial taxa associated with euploid and viable pregnancy, confined to sporadic miscarriage