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Table 2 Inverse variance weighted univariable Mendelian randomization results for age at first sex and number of sexual partners on risk of oropharyngeal cancer, by region

From: Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

Outcome

Region

N SNPs

Outcome

N

Control

N

Method

OR

CIL

CIU

P value

Age at first sex

         

Oropharyngeal cancer

Europe

139

1090

2928

IVW

0.36

0.17

0.78

< 0.001

Oropharyngeal cancer

North America

139

1119

2329

IVW

0.41

0.20

0.83

0.01

Oropharyngeal cancer

South America

139

205

727

IVW

0.38

0.07

1.95

0.24

Number of sexual partners

         

Oropharyngeal cancer

Europe

117

1090

2928

IVW

1.48

0.66

3.33

0.35

Oropharyngeal cancer

North America

117

1119

2329

IVW

2.99

1.37

6.51

0.01

Oropharyngeal cancer

South America

117

205

727

IVW

2.68

0.56

12.75

0.22

  1. Abbreviations: SNPs, single-nucleotide polymorphisms; IVW, Inverse variance weighted; SE, standard error; OR, odds ratio; CIL, lower confidence interval; CIU, upper confidence interval; P p value. OR represents the exponential change in odds of oropharyngeal squamous cell carcinoma per SD change (7.3-month delay) in age at first sex/ or per SD increase (0.94) in number of sexual partners