Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

Table 2 Inverse variance weighted univariable Mendelian randomization results for age at first sex and number of sexual partners on risk of oropharyngeal cancer, by region

Outcome	Region	N SNPs	Outcome N	Control N	Method	OR	CIL	CIU	P value
Age at first sex
Oropharyngeal cancer	Europe	139	1090	2928	IVW	0.36	0.17	0.78	< 0.001
Oropharyngeal cancer	North America	139	1119	2329	IVW	0.41	0.20	0.83	0.01
Oropharyngeal cancer	South America	139	205	727	IVW	0.38	0.07	1.95	0.24
Number of sexual partners
Oropharyngeal cancer	Europe	117	1090	2928	IVW	1.48	0.66	3.33	0.35
Oropharyngeal cancer	North America	117	1119	2329	IVW	2.99	1.37	6.51	0.01
Oropharyngeal cancer	South America	117	205	727	IVW	2.68	0.56	12.75	0.22

Abbreviations: SNPs, single-nucleotide polymorphisms; IVW, Inverse variance weighted; SE, standard error; OR, odds ratio; CIL, lower confidence interval; CIU, upper confidence interval; P p value. OR represents the exponential change in odds of oropharyngeal squamous cell carcinoma per SD change (7.3-month delay) in age at first sex/ or per SD increase (0.94) in number of sexual partners

ISSN: 1741-7015