Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

Table 4 Multivariable Mendelian randomization for number of sexual partners with risk of oropharyngeal cancer

Exposure	Exposure dataset	N SNPs	Conditional F-stat	Q-stat	P value for instrument validity	Method	NSP OR	95% CI	P
Age at first sex	UK Biobank [28]	152	7.26	214.14	3.77 × 10^-4	IVW	0.79	0.32, 1.96	0.60
						MR-Egger	0.97	0.35, 2.65	0.95
Comprehensive Smoking Index	UK Biobank [53]	157	12.18	168.74	0.20	IVW	0.91	0.48, 1.72	0.76
						MR-Egger	0.86	0.39, 1.88	0.70
Smoking initiation	GSCAN [51]	195	7.35	204.67	0.25	IVW	1.51	0.77, 2.97	0.23
						MR-Egger	1.66	0.66, 4.15	0.28
Drinks per week	GSCAN [51]	117	22.7	151.65	0.011	IVW	1.45	0.75, 2.79	0.27
						MR-Egger	1.61	0.76, 3.41	0.21
Risk tolerance	UK Biobank [26]	125	7.06	145.56	0.072	IVW	2.04	0.93, 4.44	0.07
						MR-Egger	2.12	0.66, 6.83	0.21
Educational attainment	SSAGC and UK Biobank [52]	317	42.37	326.36	0.28	IVW	1.67	0.95, 2.97	0.07
						MR-Egger	1.20	0.51, 2.83	0.67

Abbreviations: IVW, inverse variance weighted; NSP, number of sexual partners; OR, odds ratio; CI, confidence intervals; P p value; Q-stat, Cochran’s Q statistic; F-stat, conditional F-statistic; Social Science Genetic Association Consortium (SSGAC). NSP OR represents the odds ratio of oropharyngeal squamous cell carcinoma per SD increase (0.94) in the number of sexual partners

ISSN: 1741-7015