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Fig. 1 | BMC Medicine

Fig. 1

From: Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis

Fig. 1

Overall study design. GWAS summary statistics on PCOS and 4 obesity-related traits (adult BMI, childhood BMI, WHR, and WHRadjBMI) were retrieved. First, we quantified the genome-wide and local genetic correlation between PCOS and obesity-related traits. Next, we identified shared loci contributing to PCOS and obesity-related traits, and further, conducted tissue enrichment analysis, and constructed 99% credible sets of causal variants for these loci. Finally, we conducted a bidirectional Mendelian randomization analysis to infer causality between obesity-related traits and PCOS

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BMC Medicine

ISSN: 1741-7015

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