Fig. 3
Estimates of causal effect sizes for genetically predicted obesity-related traits on PCOS using all genome-wide significant SNPs, excluding pleiotropic SNPs and excluding palindromic SNPs. Inverse-variance weighted approach was used as the primary analysis, MR-Egger and weighted median approaches were used as sensitivity analysis. BMI, adult body mass index; PCOS, polycystic ovary syndrome; WHR, waist-to-hip ratio; WHRadjBMI, waist-to-hip ratio adjusted for body mass index; CBMI, childhood body mass index