Fig. 3

Vaccination with AZD1222 and BNT162b2 induced significant yet transient alterations among peripheral plasmablasts. AZD1222 also induced a significant increase in late memory B cells on days 13 and 20. A Pseudocolor plots for the expression of CD27 and CD38 on B cells are representative for the AZD1222 vaccination group. B Proportions of CD27⁺CD38^bright plasmablasts (top) and CD27⁺CD38^– late memory B cells (bottom) after vaccination with AZD1222 (n = 18, left) or BNT162b2 (n = 18, right). All FACS analyses were on CD19⁺CD45RA⁺ B cells. p-values resulting from one-way ANOVAs were < 0.0001 for both AZD1222 analyses. p-values resulting from Kruskal-Wallis and Dunn’s multiple comparisons tests were 0.0008 for the comparison of plasmablast and 0.6998 for the comparison of late memory B cells for the BNT162b2 analyses. *p < 0.05, **p < 0.01, ***p < 0.0001