Table 1 Demographic and lifestyle characteristics at index date, by study group

Count

25,598

5081

15,032

3905

1580

Age, median (IQR), years

41 (29–54)

43 (30–58)

38 (27–50)

48 (37–60)

40 (30–50)

Sex, no. (%)

 Male

10,617 (41.5%)

2609 (51.3%)

5937 (39.5%)

1346 (34.5%)

725 (45.9%)

 Female

14,981 (58.5%)

2472 (48.7%)

9095 (60.5%)

2559 (65.5%)

855 (54.1%)

Ethnicity, no. (%)^a

 Asian or Asian British

457 (2.4%)

110 (2.9%)

241 (2.2%)

83 (2.7%)

23 (2.1%)

 Black or Black British

274 (1.5%)

41 (1.1%)

159 (1.5%)

57 (1.9%)

17 (1.5%)

 Mixed

167 (0.9%)

38 (1.0%)

99 (0.9%)

19 (0.6%)

11 (1.0%)

 Chinese or other ethnic groups

219 (1.2%)

35 (0.9%)

140 (1.3%)

32 (1.0%)

12 (1.1%)

 White

17,692 (94.1%)

3622 (94.2%)

10,151 (94.1%)

2870 (93.8%)

1049 (94.3%)

Missing ethnicity, no. (%)

6789 (26.5%)

1235 (24.3%)

4242 (28.2%)

844 (21.6%)

468 (29.6%)

Deprivation score (Townsend quintile), no. (%)^a

 1 (least deprived)

4977 (19.5%)

893 (17.6%)

2944 (19.6%)

806 (20.6%)

334 (21.2%)

 2

5126 (20.0%)

982 (19.3%)

2996 (20.0%)

778 (19.9%)

370 (23.4%)

 3

5514 (21.6%)

1066 (21.0%)

3241 (21.6%)

861 (22.0%)

346 (21.9%)

 4

5587 (21.8%)

1129 (22.2%)

3343 (22.3%)

839 (21.5%)

276 (17.5%)

 5 (most deprived)

4372 (17.1%)

1006 (19.8%)

2492 (16.6%)

621 (15.9%)

253 (16.0%)

Missing deprivation score, no. (%)

30 (0.1%)^b

5 (0.1%)

16 (0.1%)

< 5

< 5

Practice region, no. (%)

 North East

530 (2.1%)

120 (2.4%)

289 (1.9%)

93 (2.4%)

28 (1.8%)

 North West

4524 (17.7%)

1277 (25.1%)

2419 (16.1%)

592 (15.2%)

236 (14.9%)

 Yorkshire and the Humber

780 (3.0%)

127 (2.5%)

493 (3.3%)

131 (3.4%)

29 (1.8%)

 East Midlands

656 (2.6%)

94 (1.9%)

439 (2.9%)

105 (2.7%)

18 (1.1%)

 West Midlands

3188 (12.5%)

525 (10.3%)

1963 (13.1%)

443 (11.3%)

257 (16.3%)

 East of England

2286 (8.9%)

359 (7.1%)

1327 (8.8%)

384 (9.8%)

216 (13.7%)

 South West

3572 (14.0%)

782 (15.4%)

1939 (12.9%)

608 (15.6%)

243 (15.4%)

 South Central

3288 (12.8%)

562 (11.1%)

1957 (13.0%)

624 (16.0%)

145 (9.2%)

 London

2628 (10.3%)

479 (9.4%)

1622 (10.8%)

381 (9.8%)

146 (9.2%)

 South East Coast

4146 (16.2%)

756 (14.9%)

2584 (17.2%)

544 (13.9%)

262 (16.6%)

BMI, median (IQR)^a

26.2 (22.8–30.7)

25.6 (22.4–29.7)

26.1 (22.7–30.5)

27.2 (23.5–32.1)

26.6 (23.1–31.1)

Missing BMI, no. (%)

7338 (28.7%)

1529 (30.1%)

4541 (30.2%)

818 (20.9%)

450 (28.5%)

Smoking status, no. (%)^a

 Never

9941 (40.0%)

1854 (37.6%)

5903 (40.6%)

1525 (39.7%)

659 (43.2%)

 Former

6762 (27.2%)

1300 (26.4%)

3853 (26.5%)

1197 (31.1%)

412 (27.0%)

 Current

8146 (32.8%)

1771 (36.0%)

4797 (33.0%)

1124 (29.2%)

454 (29.8%)

Missing smoking status, no. (%)

749 (2.9%)

156 (3.1%)

479 (3.2%)

59 (1.5%)

55 (3.5%)

Alcohol intake, no. (%)^a

 Non-drinker

3320 (33.3%)

647 (31.6%)

1945 (34.2%)

543 (32.0%)

185 (34.1%)

 Former drinker

1438 (14.4%)

334 (16.3%)

764 (13.4%)

272 (16.0%)

68 (12.5%)

 Occasional drinker

4226 (42.4%)

825 (40.3%)

2416 (42.5%)

753 (44.3%)

232 (42.8%)

 Moderate drinker

467 (4.7%)

104 (5.1%)

264 (4.6%)

72 (4.2%)

27 (5.0%)

 Heavy drinker

520 (5.2%)

138 (6.7%)

293 (5.2%)

59 (3.5%)

30 (5.5%)

Missing alcohol intake, no. (%)

15,627 (61.0%)

3033 (59.7%)

9350 (62.2%)

2206 (56.5%)

1038 (65.7%)