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Table 2 Treatment-related adverse events

From: Activity and safety of SHR3680, a novel antiandrogen, in patients with metastatic castration-resistant prostate cancer: a phase I/II trial

 

All patients ( N = 197)

Any grade

Grade ≥3

Any

116 (58.9)

23 (11.7)

Proteinuria

27 (13.7)

0

Hot flush

22 (11.2)

0

White blood cell count decreased

19 (9.6)

3 (1.5)

Neutrophil count decreased

14 (7.1)

2 (1.0)

Asthenia

13 (6.6)

0

Occult blood positive

12 (6.1)

0

Aspartate aminotransferase increased

12 (6.1)

0

Bilirubin conjugated increased

11 (5.6)

0

Platelet count decreased

10 (5.1)

0

Alanine aminotransferase increased

9 (4.6)

1 (0.5)

Blood thyroid stimulating hormone increased

8 (4.1)

0

Hypertriglyceridemia

7 (3.6)

1 (0.5)

Decreased appetite

7 (3.6)

1 (0.5)

Hypertension

7 (3.6)

2 (1.0)

Gynecomastia

7 (3.6)

1 (0.5)

Anemia

7 (3.6)

1 (0.5)

  1. Data are N (%). Treatment-related adverse events of any grade occurring in ≥3% of total patients are listed