Fig. 1
From: Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants
Overview of the study. a We first processed the ChIP-Seq data (from human brain or neuronal cells) to derive the binding motifs of the transcription factors (TFs). b We then investigated if the index SNPs (or SNPs in LD with the index SNPs) disrupt binding of TFs using find individual motif occurrences (FIMO). c Finally, a series of experiments and analyses were conducted to validate the regulatory effects of the TF binding-disrupting SNPs