Fig. 5
From: Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants
Disruption of CTCF, RAD21, and SMC3 binding by SNP rs11575895. a–c Disruption of CTCF, RAD21, and SMC3 binding by SNP rs11575895. d SNP rs11575895 is located in a genomic region with strongly DNase-Seq, ChIP-Seq, and histone modification signals, indicating that rs11575895 is located in a region of active transcription in neuronal cells. e SNP rs11575895 is located in the first exon of the longest transcript of MAPT. f Reporter gene assays exhibited that the G allele of rs11575895 conferred significantly higher luciferase activity than the A allele in SH-SY5Y and U251 cells. N = 8 for the control group, n = 16 per experimental group for SH-SY5Y and U251 cells. Two-tailed Student’s t test was used for statistical analyses. **P < 0.01, ***P < 0.001