Heart rate variability is associated with left ventricular systolic, diastolic function and incident heart failure in the general population

Arshi, Banafsheh; Geurts, Sven; Tilly, Martijn J.; van den Berg, Marten; Kors, Jan A.; Rizopoulos, Dimitris; Ikram, M. Arfan; Kavousi, Maryam

doi:10.1186/s12916-022-02273-9

Table 2 Longitudinal associations of RMSSDc and SDNNc with echocardiographic parameters of left ventricular systolic and diastolic function in men and women

From: Heart rate variability is associated with left ventricular systolic, diastolic function and incident heart failure in the general population

		RMSSDc^a				SDNNc^a
		Men		Women		Men		Women
		β (95% CI)	p-value	β (95% CI)	p-value	β (95% CI)	p-value	β (95% CI)	p-value
LVEF	HRV^b	-0.75 (− 1.11 to − 0.39)	< 0.001	− 0.31 (− 0.60 to − 0.01)	0.042	− 0.72 (− 1.10 to − 0.34)	< 0.001	− 0.27 (− 0.59 to 0.05)	0.100
	HRV *time	− 0.02 (− 0.18 to 0.15)	0.831	− 0.10 (− 0.22 to 0.03)	0.145	0.02 (− 0.16 to 0.19)	0.870	−0.10 (− 0.23 to 0.04)	0.156
	HRV *time²	0.01 (−0.01 to 0.03)	0.189	0.01 (−0.004 to 0.03)	0.153	0.01 (−0.01 to 0.04)	0.246	0.01 (−0.004 to 0.03)	0.165
E/A	HRV	−0.03 (− 0.04 to − 0.01)	< 0.001	−0.02 (− 0.03 to − 0.003)	0.019	−0.02 (− 0.03 to − 0.01)	0.007	−0.01 (− 0.02 to 0.01)	0.399
E/A	HRV *time	0.002 (0.001 to 0.01)	0.067	0.001 (−0.002 to 0.004)	0.473	0.001 (−0.001 to 0.01)	0.260	−0.001 (− 0.01 to 0.002)	0.707
LA diameter	HRV	0.23 (−0.26 to 0.73)	0.356	−0.72 (− 1.20 to − 0.25)	0.003	0.19 (− 0.34 to 0.72)	0.482	- 0.53 (− 1.02 to − 0.03)	0.037
LA diameter	HRV *time	− 0.06 (− 0.14 to 0.02)	0.114	0.08 (0.01 to 0.16)	0.025	− 0.08 (− 0.17 to 0.002)	0.056	0.04 (− 0.03 to 0.12)	0.258
E/e’	HRV	− 0.09 (− 0.21 to 0.04)	0.165	0.01 (− 0.13 to 0.15)	0.890	− 0.11 (− 0.25 to 0.02)	0.101	0.03 (− 0.12 to 0.19)	0.678
E/e’	HRV *time	0.03 (− 0.03 to 0.09)	0.346	0.03 (− 0.04 to 0.10)	0.392	0.03 (− 0.04 to 0.09)	0.396	0.01 (− 0.06 to 0.08)	0.815
LVM index	HRV	− 1.76 (−2.77 to − 0.75)	0.001	− 1.18 (− 1.99 to − 0.38)	0.004	−1.83 (− 2.91 to − 0.76)	0.001	−1.35 (− 2.22 to − 0.49)	0.002
LVM index	HRV *time	0.0002 (− 0.21 to 0.21)	0.999	−0.09 (− 0.26 to 0.09)	0.327	0.004 (− 0.23 to 0.24)	0.970	− 0.15 (− 0.33 to 0.03)	0.111

^a Values of RMSSDc and SDNNc have been natural log transformed
^bexposure (RMSSDc or SDNNc)
RMSSDc root mean square of successive RR-interval differences corrected for heart rate, SDNNc standard deviation of normal R-R intervals corrected for heart rate, LVEF Left ventricular ejection fraction, E/A mitral E wave/ A wave ratio, LA diameter left atrial diameter, E/e’ E wave/ septal e’ ratio, LVM index left ventricular mass index. Analyses are adjusted for age, hypertension, diabetes, CHD, total cholesterol and HDL, use of lipid lowering and cardiac medication and BMI

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ISSN: 1741-7015

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