High polygenic predisposition for ADHD and a greater risk of all-cause mortality: a large population-based longitudinal study

Table 2 Cox regression analyses highlighting associations between PGD-ADHD_single and risk for all-cause mortality during a follow-up period

Polygenic scores for ADHD	The whole sample				Men				Women
Polygenic scores for ADHD	HR	95% CI	p	R²	HR	95% CI	p	R²	HR	95% CI	p	R²
Participants all ages
PGD-ADHD_single	1.06	1.02–1.12	0.010	0.07%	1.07	1.00–1.14	0.043	0.09%	1.06	0.99–1.13	0.121	0.05%
Participants aged 50–75 years at start
PGD-ADHD_single	1.09	1.03–1.17	0.006	0.11%	1.12	1.03–1.22	0.006	0.24%	1.05	0.96–1.16	0.284	0.03%

Model was adjusted for baseline age, sex, interaction between age, sex and first 4 PCs to adjust for genetic ancestry; to capture non-linear effects of ageing, we included age² and age³ as covariates
ADHD attention deficit hyperactivity disorder, HR hazard ratio, CI confidence intervals

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