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Table 3 Taxa regulated by inulin and/or PA in the gut microbiota of mice

From: Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals

 

Mean ± SEM

Kruskal-Wallis test

LF

HF

INU

Ex

INU+ Ex

p-value

q-value

Phylum

 Firmicutes

51.31 ± 1.3a

53.888 ± 2.866a

41.956 ± 1.555b

51.511 ± 1.468a

40.511 ± 2.228b

< 0.001

< 0.001

 Bacteroidetes

37.09 ± 1.357ab

31.25 ± 1.885b

47.9 ± 1.123 ac

35.378 ± 1.05b

49.1 ± 1.553c

< 0.001

< 0.001

 Actinobacteria

0.091 ± 0.026a

0.072 ± 0.016a

1.054 ± 0.243b

0.112 ± 0.029a

0.334 ± 0.149ab

0.001

0.002

 Proteobacteria

6.092 ± 0.751ab

8.386 ± 1.38a

4.502 ± 0.688b

8.763 ± 0.902a

6.182 ± 0.571ab

0.005

0.008

Family

 Lachnospiraceae

7.789 ± 0.935a

6.3 ± 0.812ab

5.081 ± 1.016b

6.221 ± 0.614ab

4.497 ± 0.623ab

0.024

0.035

 Ruminococcaceae

27.91 ± 1.44a

28.65 ± 2.351ab

16.678 ± 1.5bc

28.867 ± 1.047a

9.791 ± 0.689c

< 0.001

< 0.001

 Coriobacteriaceae

0.087 ± 0.025ab

0.063 ± 0.014ab

0.209 ± 0.071a

0.09 ± 0.025ab

0.056 ± 0.02b

0.017

0.029

 Rikenellaceae

11.562 ± 1.723ab

11.866 ± 1.499ab

8.651 ± 1.26ab

13.822 ± 0.855a

5.727 ± 0.391b

0.002

0.005

 Prevotellaceae

0.673 ± 0.131ab

0.651 ± 0.213ab

1.419 ± 0.348ab

0.39 ± 0.056a

1.492 ± 0.267b

0.003

0.005

 Clostridiales_Incertae_Sedis_XIII

0.089 ± 0.011a

0.079 ± 0.009ab

0.038 ± 0.007ab

0.092 ± 0.017a

0.032 ± 0.005b

0.001

0.003

 Bifidobacteriaceae

0 ± 0a

0 ± 0a

0.842 ± 0.195b

0.015 ± 0.007ab

0.276 ± 0.133b

< 0.001

< 0.001

 Peptostreptococcaceae

0.262 ± 0.09a

0.313 ± 0.068a

0.002 ± 0.001b

0.468 ± 0.275a

0.002 ± 0.002b

< 0.001

< 0.001

 Desulfovibrionaceae

0.263 ± 0.021a

0.342 ± 0.049ab

0.318 ± 0.075ab

0.594 ± 0.093b

0.168 ± 0.038a

0.002

0.005

Genus

 Oscillibacter

8.902 ± 0.597ab

10.54 ± 1.009ab

6.264 ± 0.794bc

10.742 ± 0.524a

2.768 ± 0.334c

< 0.001

< 0.001

 Clostridium_IV

0.375 ± 0.054a

0.176 ± 0.013ab

0.118 ± 0.032b

0.163 ± 0.022ab

0.086 ± 0.016b

< 0.001

< 0.001

 Alistipes

11.562 ± 1.723ab

11.853 ± 1.496a

8.634 ± 1.255ab

13.822 ± 0.855a

5.718 ± 0.392b

0.002

0.003

 Prevotella

0.173 ± 0.04a

0.042 ± 0.019b

0.106 ± 0.025ab

0.054 ± 0.012ab

0.165 ± 0.028a

0.003

0.005

 Parabacteroides

1.869 ± 0.402a

0.113 ± 0.031b

0.143 ± 0.032b

0.343 ± 0.11b

0.895 ± 0.285ab

< 0.001

< 0.001

 Ruminococcus

0.017 ± 0.006ab

0.013 ± 0.005a

0.071 ± 0.032ab

0.018 ± 0.005ab

0.115 ± 0.044b

0.004

0.006

 Bifidobacterium

0 ± 0a

0 ± 0a

0.842 ± 0.195b

0.015 ± 0.007ab

0.276 ± 0.133b

< 0.001

< 0.001

 Eisenbergiella

0.112 ± 0.052a

0.008 ± 0.002ab

0.001 ± 0b

0.01 ± 0.002ab

0.004 ± 0.002b

< 0.001

< 0.001

 Clostridium_XlVb

0.049 ± 0.025a

0.006 ± 0.002ab

0 ± 0b

0.063 ± 0.02a

0.001 ± 0.001b

< 0.001

< 0.001

 Macellibacteroides

0.015 ± 0.003ab

0.002 ± 0.001a

0.002 ± 0.001a

0.005 ± 0.004a

0.048 ± 0.017b

< 0.001

< 0.001

 Romboutsia

0.262 ± 0.09a

0.313 ± 0.068a

0.002 ± 0.001b

0.468 ± 0.275a

0.002 ± 0.002b

< 0.001

< 0.001

 Saccharibacteria_genera_incertae_sedis

0.017 ± 0.006

0.011 ± 0.005

0.039 ± 0.011

0.011 ± 0.004

0.041 ± 0.012

0.024

0.031

 Bilophila

0.263 ± 0.021a

0.342 ± 0.049ab

0.318 ± 0.075ab

0.594 ± 0.093b

0.168 ± 0.038a

0.002

0.004

  1. The relative abundance of taxa significantly regulated by inulin or voluntary exercise in the cecal content of mice. Results are expressed as mean of relative abundance ± SEM. Significantly affected taxa by inulin or voluntary exercise were identified using a Kruskal-Wallis ANOVA performed in R. p-value was adjusted (q-value, significant if q < 0.05) to control for the false discovery rate (FDR correction) for multiple testing. Ns Not significant. Multiples comparisons were then assessed using Dunn’s post hoc test in R. A different letter was attributed to the groups when the variations between groups are significantly different