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Table 1 Baseline and perinatal characteristics of the study population

From: The association between assisted reproductive technology and cardiac remodeling in fetuses and early infants: a prospective cohort study

Characteristics

SC (n = 85)

ART (n = 88)

P

Maternal characteristics

 Age (years)

33.0 (31.5, 36.0)

34.0 (31.0, 36.0)

0.793

 BMI (kg/m2)

26.11±3.44

25.74 (24.06, 28.29)

0.500

 Han, % (n)

85.88 (73)

86.36 (76)

0.927

 Nulliparity, % (n)

56.47 (48)

89.77 (79)

<0.001

 Family cardiovascular history, % (n)a

57.65 (49)

48.86 (43)

0.247

 Low socioeconomic level, % (n)

18.82 (16)

28.41 (25)

0.138

 University education, % (n)

87.06 (74)

70.45 (62)

0.008

Paternal characteristics

 Age (years)

34.8±4.3

35.7±4.1

0.165

 BMI (kg/m2)

25.77±3.34

25.32±3.48

0.386

 Han, % (n)

88.24 (75)

88.64 (78)

0.934

 Cigarette smoker, % (n)

34.12 (29)

43.18 (38)

0.221

 Family cardiovascular history, % (n)a

57.65 (49)

53.41 (47)

0.575

 Low socioeconomic level, % (n)

5.88 (5)

13.64 (12)

0.087

 University education, % (n)

85.88 (73)

70.45 (62)

0.014

Fertility and ART characteristics

 Infertility cause, % (n)

  Unexplained

-

12.50 (11)

-

  Female

-

45.45 (40)

-

  Male

-

18.18 (16)

-

  Female + male

-

23.86 (21)

-

 ART technique, % (n)

  IVF

-

54.55 (48)

-

  ICSI

-

43.18 (38)

-

  IVF+ICSI

-

2.27 (2)

-

 Transferred embryos, % (n)

  1

-

25.00 (22)

-

  2

-

73.86 (65)

-

  3

-

1.14 (1)

-

 FET, % (n)

-

76.14 (67)

-

Pregnancy complications, % (n)

 Preeclampsia

4.71 (4)

9.09 (8)

0.256

 Gestational diabetes

23.53 (20)

18.18 (16)

0.386

 Placenta previa

2.35 (2)

4.55 (4)

0.710

 Obstetric cholestasis

0 (0)

0 (0)

1.000

 Prenatal corticoid exposure

1.18 (1)

2.27 (2)

1.000

Delivery data

 Gestational age at delivery (week)

39.6±1.0

39.5±0.9

0.694

 Cesarean section, % (n)

48.24 (41)

72.73 (64)

0.001

 Male, % (n)

47.06 (40)

52.27 (46)

0.493

 Birth length (cm)

51.0 (49.5, 52.0)

51.0 (50.0, 52.0)

0.559

 Birth weight (g)

3380±280

3448±316

0.138

Neonatal outcome, % (n)

 Admission to NICU

1.18 (1)

0 (0)

0.491

 Major neonatal morbidityb

0 (0)

0 (0)

1.000

 Perinatal mortality

0 (0)

0 (0)

1.000

  1. ART Pregnancy conceived by assisted reproductive technologies, BMI Body mass index, FET Frozen embryo transfer, ICSI Intracytoplasmic sperm injection, IVF In vitro fertilization, NICU Neonatal intensive care unit, SC Spontaneous conception
  2. aFamily cardiovascular history is defined as the existence of congenital heart disease, coronary disease, hypertension, diabetes, hypercholesterolemia, or stroke in men<55 years and women<65 years
  3. bMajor neonatal morbidity is defined as the existence of bronchopulmonary dysplasia, necrotising enterocolitis, intraventricular haemorrhage, periventricular leukomalacia, retinopathy, persistent ductus arteriosus, or sepsis in the first 28 days of life