Fig. 1

Cumulative Incidence of Stroke by CKD stage (A) and CKD risk category (B). CKD was classified according to the KDIGO clinical practice guidelines: (1) no CKD defined as eGFR ≥ 60 and UACR < 30; (2) CKD G1, as eGFR ≥ 90 and UACR ≥ 30; (3) CKD G2, as eGFR between 60 and 89 and UACR ≥ 30; (4) CKD G3, as eGFR between 30 and 59 regardless of UACR. CKD risk categories were defined by eGFR and UACR as follows: (1) low risk, as eGFR ≥ 60 and UACR < 30; (2) moderate risk, as (45 ≤ eGFR < 60 and UACR < 30) or (eGFR ≥ 60 and 30 ≤ UACR ≤ 300); (3) high risk, as (30 ≤ eGFR < 44 and UACR< 30) or (45 ≤ eGFR < 60 and 30 ≤ UACR ≤ 300) or (eGFR ≥ 60 and UACR > 300); (4) very high risk, as (30 ≤ eGFR < 44 and 30 ≤ UACR ≤ 300) or (30 ≤ eGFR < 60 and UACR > 300). CKD indicates chronic kidney disease; eGFR, estimated glomerular filtration rate; KDIGO, Kidney Disease: Improving Global Outcomes; UACR, urine albumin-creatinine ratio