Fig. 1

Flowchart detailing the process of identifying previously reported risk factors with suitable genetic instruments. TNF-α = tumour necrosis factor-α, IGFBP-1 = insulin-like growth factor-binding protein-1, LDL = low-density lipoprotein, HDL = high-density lipoprotein, IGF-1 = insulin-like growth factor-1, IL-6 = interleukin-6, CRP = C-reactive protein, SHBG = sex hormone-binding globulin