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Table 5 Results of multivariable MR mediation analysis

From: Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis

Mediator

Outcome

Direct effect of BMI on outcome

Indirect effect of mediator on outcome

% mediated (95% CI)

P value

Fasting insulin

Overall Endometrial Cancer

1.75

1.07

11% (1 to 21%)

2.89 × 10−2

Endometrioid Endometrial Cancer

1.72

1.11

16% (3 to 28%)

1.24 × 10−2

Bioavailable testosterone

Overall Endometrial Cancer

1.70

1.11

15% (10 to 20%)

1.43 × 10−8

Endometrioid Endometrial Cancer

1.72

1.11

15% (9 to 22%)

2.15 × 10−6

SHBG

Overall Endometrial Cancer

1.80

1.04

7% (1 to 12%)

1.81 × 10−2

Endometrioid Endometrial Cancer

1.86

1.02

2% (− 9 to 14%)

6.87 × 10−1

  1. Direct effect is defined as the remaining effect of the exposure (BMI) on the outcome (endometrial cancer risk) when the effect of the candidate mediator on the outcome has been adjusted for. Indirect effect is defined as the effect of the exposure (BMI) on the outcome (endometrial cancer risk) through the candidate mediator. SHBG sex hormone-binding globulin
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BMC Medicine

ISSN: 1741-7015

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