Table 1 Differences between spontaneous preterm and spontaneous term birth in the human placental proteome
From: Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth
Spot | Protein | UniProt-KB | Description | Theoretical pI/ MW (kDa) | Detected pI/ MW (kDa) | Ratio | |
|---|---|---|---|---|---|---|---|
T vs P | |||||||
Ch | Ba | ||||||
26 | AAT | P01009 | α-1-antitrypsin (isoform 1) | 5.37 47 (5.37 44) | 4.92 60 | (− 1.28) | − 1.50 |
27 | AAT | P01009 | α-1-antitrypsin (isoform 1) | 4.97 59 | − 1.45 | − 1.63 | |
38 | AAT | P01009 | α-1-antitrypsin (isoform 1,2) | 4.82 51 | − 2.39 | (− 2.01) | |
39 | AAT | P01009 | α-1-antitrypsin (isoform 1,2) | 4.86 51 | − 2.16 | (− 1.82) | |
85* | ACTB | P60709 | Actin, cytoplasmic 1 (fragment) | 5.29 42 (5.29 42) | 4.93 18 | (1.33) | 2.48 |
18 | ALB | P02768 | Serum albumin | 5.92 69 | 5.71 66 | (− 1.05) | − 1.52 |
84* | ANXA5 | P08758 | Annexin A5 (fragment) | 4.93 36 (4.93 36) | 4.83 18 | (1.35) | 2.19 |
67 | APCS | P02743 | Serum amyloid P-component | 6.10 25 (6.12 25) | 5.52 25 | − 2.42 | − 1.62 |
73 | APOA1 | P02647 | Apolipoprotein A-I | 5.56 31 | 5.09 23 | (− 1.44) | − 1.52 |
58 | CLU | P10909 | Clusterin (isoform 3) | 6.19 32 | 4.76 36 | − 3.08 | − 1.96 |
59 | CLU | P10909 | Clusterin (isoform 3) | 4.82 35 | − 2.98 | (− 1.75) | |
60 | CLU | P10909 | Clusterin (isoform 3) | 4.88 34 | − 2.99 | (− 1.49) | |
23 | CPNE1 | Q99829 | Copine-1 | 5.52 59 | 5.56 63 | 1.62 | 1.95 |
9 | EEF2 | P13639 | Elongation factor 2 | 6.41 95 (6.42 95) | 6.42 95 | 2.60 | 1.94 |
48* | FGB | P02675 | Fibrinogen ß chain (C-terminal fragment) | 8.54 56 (7.95 51) | 5.51 38 | − 2.89 | (− 1.44) |
49* | FGB | P02675 | Fibrinogen ß chain (C-terminal fragment) | 5.60 39 | − 3.04 | (− 1.39) | |
50* | FGB | P02675 | Fibrinogen ß chain (C-terminal fragment) | 5.71 39 | − 2.84 | (− 1.44) | |
51* | FGB | P02675 | Fibrinogen ß chain (C-terminal fragment) | 5.85 38 | − 2.46 | (− 1.35) | |
11 | FGG | P02679 | Fibrinogen γ (isoform γ-B,A) | 5.37 52 (5.24 48) | 5.41 95 | − 3.59 | (− 1.99) |
12 | FGG | P02679 | Fibrinogen γ (isoform γ-B,A) | 5.47 94 | − 3.42 | (− 1.83) | |
13 | FGG | P02679 | Fibrinogen γ (isoform γ-B,A) | 5.54 94 | − 2.91 | (− 1.68) | |
14 | FGG | P02679 | Fibrinogen γ (isoform γ-B,A) | 5.58 94 | − 2.67 | (− 1.57) | |
78 | FTL | P02792 | Ferritin light chain | 5.50 20 (5.50 20) | 5.50 20 | (1.29) | − 2.73 |
8 | GSN | P06396 | Gelsolin (isoform 1) | 5.90 86 (5.72 83) | 5.82 95 | − 1.94 | − 1.79 |
89 | HBG1/2 | P69891/2 | Hemoglobin subunit gamma-1/2 | 6.64 16 (6.71 16) | 6.36 12 | (1.38) | 2.55 |
28 | HNRNPK | P61978 | Heterogeneous nuclear ribonucleoprotein K (isoform 1-3) | 5.39 51 | 5.39 57 | 2.06 | (1.33) |
17 | HSPA5 | P11021 | 78 kDa glucose-regulated protein | 5.07 72 (5.01 70) | 5.01 71 | 2.60 | 2.73 |
1 | ITIH4 | Q14624 | Inter-α-trypsin inhibitor heavy chain H4 (isoform 1) | 6.51 103 (6.11 100) | 4.90 137 | (− 1.08) | − 1.53 |
2 | ITIH4 | Q14624 | Inter-α-trypsin inhibitor heavy chain H4 (isoform 1) | 4.92 136 | (− 1.00) | − 1.58 | |
3 | ITIH4 | Q14624 | Inter-α-trypsin inhibitor heavy chain H4 (isoform 1) | 4.94 135 | (− 1.05) | − 1.63 | |
4 | ITIH4 | Q14624 | Inter-α-trypsin inhibitor heavy chain H4 (isoform 1) | 4.96 135 | (− 1.18) | − 1.56 | |
30 | KRT8 | P05787 | Keratin, type II cytoskeletal 8 (isoform 1,2) | 5.52 54 | 5.24 47 | − 1.55 | (− 1.34) |
31 | KRT8 | P05787 | Keratin, type II cytoskeletal 8 (isoform 1,2) | 5.33 50 | − 2.48 | (− 1.54) | |
54* | KRT8 | P05787 | Keratin, type II cytoskeletal 8 (isoform 1,2; fragment) | 4.85 38 | − 5.02 | (− 3.82) | |
57* | KRT8 | P05787 | Keratin, type II cytoskeletal 8 (isoform 1,2; fragment) | 4.79 37 | − 4.70 | (− 3.49) | |
5 | KRT18 | P05783 | Keratin, type I cytoskeletal 18 | 5.34 48 (5.34 48) | 5.29 102 | − 2.03 | (− 1.83) |
6 | KRT18 | P05783 | Keratin, type I cytoskeletal 18 | 5.35 102 | − 2.19 | (− 2.07) | |
56* | KRT19 | P08727 | Keratin, type I cytoskeletal 19 (C-terminal fragment) | 5.05 44 | 4.74 37 | − 2.28 | (− 1.99) |
79 | NUDT16 | Q96DE0 | U8 snoRNA-decapping enzyme (isoform 1) | 6.38 21 | 6.33 21 | 2.54 | (4.78) |
10 | TF | P02787 | Serotransferrin | 6.81 77 (6.70 75) | 6.02 90 | 2.43 | 1.95 |
80 | TAGLN2 | P37802 | Transgelin-2 (isoform 1,2) | 8.41 22 (8.45 22) | 5.59 19 | − 1.91 | − 1.75 |
41 | VIM | P08670 | Vimentin | 5.05 54 (5.05 54) | 4.71 44 | − 1.77 | − 1.69 |
24 | – | – | – | – | 5.53 56 | 2.01 | 2.04 |