Skip to main content

Table 2 Frequency of NIDIAG priority infections and of other clinical diagnoses in 1922 patients evaluated for persistent fever, per study country

From: Etiological spectrum of persistent fever in the tropics and predictors of ubiquitous infections: a prospective four-country study with pooled analysis

 

Sudan

n = 667

DR Congo

n = 300

Nepal

n = 577

Cambodia

n = 378

Total

n = 1922

NIDIAG priority conditions

 Enteric fever

11 (1.6)

9 (3.0)

8 (1.4)a

6 (1.6)

34 (1.8)

  Salmonella Typhi

9

9

5

23

  Salmonella Paratyphi A

2

3

6

11

 Leptospirosis

13 (1.8)

10 (3.3)

30 (5.2)

24 (6.3)

77 (4.0)

  Confirmed

1

5

13

12

31

  Probable

12

5

17

12

46

 Rickettsiosis

1 (0.1)

5 (1.7)

28 (4.7)

10 (2.6)

44 (2.3)

  Rickettsia typhib

5

5

8

18

  Orientia tsutsugamushic

11

2

13

  Rickettsia spp.d

1

12

13

 Relapsing fever

7 (1.0)

4 (0.7)

1 (0.3)

12 (0.6)

 Brucellosis

28 (4.2)

28 (1.5)

 Melioidosis

16 (4.2)

16 (0.8)

 Visceral leishmaniasis

65 (9.7)

56 (9.7)

119 (6.2)

 Human African trypanosomiasis

2 (0.7)

2 (0.1)

 Amebic liver abscess

1 (0.2)

11 (2.9)

12 (0.6)

 Malaria

55 (8.2)

96 (32.0)

4 (1.1)

154 (8.0)

 Tuberculosise

8 (1.2)

18 (6.0)

27 (4.7)

76 (20.1)

129 (6.7)

 New HIV diagnosis/opportunistic infection (other than tuberculosis)

4 (0.6)

4 (1.3)

4 (0.7)

2 (0.5)

14 (0.7)

Other clinical diagnoses

 Other (suspected) systemic bacterial infections

2 (0.3)

11 (3.7)

2 (0.3)

29 (7.7)

44 (2.3)

 Suspected focal bacterial infections

101 (5.3)

47 (15.7)

55 (9.5)

161 (42.6)

364 (18.9)

  Pneumonia

23 (3.4)

22 (7.3)

20 (3.5)

83 (22.0)

148 (7.7)

  Abdominal/intestinal infection

12 (1.8)

7 (2.3)

4 (0.7)

26 (6.9)

49 (2.5)

  Genitourinary infection

63 (9.4)

13 (4.3)

31 (5.4)

26 (6.9)

133 (6.5)

  Skin and soft tissue infection

3 (0.4)

5 (1.7)

26 (6.9)

34 (1.4)

 Suspected viral infection (respiratory/other)

54 (8.1)

29 (9.7)

76 (13.2)

5 (1.3)

164 (8.5)

 Other infections (parasitic, fungal)

2 (0.3)

2 (0.7)

6 (1.6)

10 (0.5)

 Non-infectious etiologies

9 (1.3)

1 (0.3)

11 (1.9)

17 (4.5)

38 (2.0)

 Unknown/unspecified cause

333 (49.9)

80 (26.7)

278 (48.2)

54 (14.3)

745 (38.8)

  1. All results are presented as n (%) except when mentioned otherwise
  2. Enteric fever was diagnosed together with another infection in 8 cases (brucellosis, n = 3; visceral leishmaniasis, n = 2; malaria, n = 2; rickettsiosis, n = 2; HIV, n = 1). Leptospirosis was diagnosed together with another infection in 13 cases (tuberculosis, n = 3; malaria, n = 2; pneumonia, n = 2; skin/soft tissue infection, n = 2; visceral leishmaniasis, n = 1; others, n = 3). Rickettsiosis was diagnosed together with another infection in 6 cases (visceral leishmaniasis, n = 4; enteric fever, n = 2)
  3. a One case of enteric fever was due to Salmonella spp. (in Nepal).
  4. b Confirmed in 12 cases, either by PCR (n = 3) or seroconversion (n = 9); probable in 6 cases
  5. c Confirmed in 4 cases either by PCR (n = 1) or seroconversion (n = 3); probable in 9 cases
  6. d Confirmed in 13 cases by PCR
  7. e Including 86 (67%) pulmonary and 43 (33%) extrapulmonary tuberculosis