Etiological spectrum of persistent fever in the tropics and predictors of ubiquitous infections: a prospective four-country study with pooled analysis

Table 5 Diagnostic performance of the study RDTs for all pooled cases of leptospirosis

	SD Bioline Leptospira IgG/IgM	Test-it^TM Leptospira IgM Lateral Flow Assay
Sensitivity	6/64 (9; 4–19)	5/31 (16; 7–33)
Specificity	1804/1853 (97.4; 96.5–98.4)	785/819 (95.8; 94.3–98.2)
Positive likelihood ratio	3.5	3.8
Negative likelihood ratio	0.93	0.88
Post-test probability if positive test (pre-test = 4.0%)^a	12.6%	13.7%
Post-test probability if negative test (pre-test = 4.0%)^a	3.7%	3.5%

Sensitivity and specificity are reported as n/n (%; 95% confidence interval)
^aPre-test probability indicates the frequency of leptospirosis in the study cohort (i.e., 4.0%)

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