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Table 5 Diagnostic performance of the study RDTs for all pooled cases of leptospirosis

From: Etiological spectrum of persistent fever in the tropics and predictors of ubiquitous infections: a prospective four-country study with pooled analysis

  SD Bioline Leptospira IgG/IgM Test-itTM Leptospira IgM Lateral Flow Assay
Sensitivity 6/64 (9; 4–19) 5/31 (16; 7–33)
Specificity 1804/1853 (97.4; 96.5–98.4) 785/819 (95.8; 94.3–98.2)
Positive likelihood ratio 3.5 3.8
Negative likelihood ratio 0.93 0.88
Post-test probability if positive test (pre-test = 4.0%)a 12.6% 13.7%
Post-test probability if negative test (pre-test = 4.0%)a 3.7% 3.5%
  1. Sensitivity and specificity are reported as n/n (%; 95% confidence interval)
  2. aPre-test probability indicates the frequency of leptospirosis in the study cohort (i.e., 4.0%)