Skip to main content

Table 1 Baseline data in the derivation and validation cohort

From: Predictive performance of a competing risk cardiovascular prediction tool CRISK compared to QRISK3 in older people and those with comorbidity: population cohort study

Characteristic Women Men
Derivation cohort
N = 989,732
Validation cohort
N = 494,865
Derivation cohort
N = 946,784
Validation cohort
N = 473,392
Smoking status recorded 789,562 (79.8) 394,819 (79.8) 651,127 (68.8) 325,555 (68.8)
Body mass index (BMI) recorded 716,715 (72.4) 358,418 (72.4) 552,983 (58.4) 276,680 (58.4)
Total cholesterol to HDL cholesterol ratio recorded 149,188 (15.1) 74,602 (15.1) 142,013 (15.0) 70,741 (14.9)
Systolic blood pressure (SBP) recorded 821,768 (83.0) 410,765 (83.0) 620,788 (65.6) 310,112 (65.5)
2 or more SBP readings recorded before baseline 525,966 (53.1) 262,696 (53.1) 245,671 (25.9) 122,884 (26.0)
Complete data for BMI, total to HDL cholesterol ratio, SBP, and smoking status 95,886 (9.7) 47,996 (9.7) 79,081 (8.4) 39,496 (8.3)
Age (years) 46.0 (15.3) 46.0 (15.3) 44.8 (13.9) 44.8 (13.9)
Townsend score − 0.6 (2.8) − 0.6 (2.8) − 0.5 (2.8) − 0.5 (2.8)
BMI (kg/m2) 25.9 (5.7) 25.9 (5.7) 26.6 (4.7) 26.6 (4.7)
Total cholesterol to HDL cholesterol ratio 3.7 (1.1) 3.7 (1.1) 4.4 (1.3) 4.4 (1.3)
Systolic blood pressure (mmHg) 125.4 (18.0) 125.4 (18.0) 131.1 (16.2) 131.1 (16.2)
Systolic blood pressure variability 10.0 (5.7) 9.9 (5.7) 10.3 (6.2) 10.3 (6.2)
Ethnicity
 Ethnicity recorded 783,626 (79.2) 391,224 (79.1) 610,093 (64.4) 305,385 (64.5)
 White or not recorded 908,817 (91.8) 454,329 (91.8) 891,002 (94.1) 445,219 (94.0)
 Indian 15,045 1.5) 7443 (1.5) 10,182 (1.1) 5140 (1.1)
 Pakistani 6411 (0.6) 3139 (0.6) 4452 (0.5) 2222 (0.5)
 Bangladeshi 1717 (0.2) 877 (0.2) 1403 (0.1) 742 (0.2)
 Other Asian 9027 0.9) 4670 (0.9) 6636 (0.7) 3337 (0.7)
 Black Caribbean 6369 (0.6) 3136 (0.6) 4455 (0.5) 2232 (0.5)
 Black African 12,420 (1.3) 6384 (1.3) 8535 (0.9) 4287 (0.9)
 Chinese 4390 (0.4) 2349 (0.5) 2325 (0.2) 1178 (0.2)
 Other 25,536 (2.6) 12,538 (2.5) 17,794 (1.9) 9035 (1.9)
Smoking status
 Non-smoker 471,885 (59.8) 235,889 (59.7) 318,933 (49.0) 159,738 (49.1)
 Former smoker 144,631 (18.3) 72,773 (18.4) 144,517 (22.2) 72,366 (22.2)
 Light smoker 56,913 (7.2) 28,364 (7.2) 50,254 (7.7) 25,006 (7.7)
 Moderate smoker 74,332 (9.4) 37,358 (9.5) 74,919 (11.5) 37,492 (11.5)
 Heavy smoker 41,801 (5.3) 20,435 (5.2) 62,504 (9.6) 30,953 (9.5)
Family history of coronary heart disease in 1st degree relative < 60 years 65,264 (6.6) 32,360 (6.5) 50,139 (5.3) 25,098 (5.3)
Type 1 diabetes 2512 (0.3) 1240 (0.3) 3227 (0.3) 1616 (0.3)
Type 2 diabetes 11,336 (1.1) 5686 (1.1) 14,147 (1.5) 6930 (1.5)
Treated hypertension 77,148 (7.8) 38,796 (7.8) 55,397 (5.9) 27,371 (5.8)
Rheumatoid arthritis 8510 (0.9) 4192 (0.8) 3111 (0.3) 1613 (0.3)
Atrial fibrillation 5412 (0.5) 2787 (0.6) 7058 (0.7) 3562 (0.8)
Chronic kidney disease (stage 3, 4, or 5) 4636 (0.5) 2282 (0.5) 3789 (0.4) 1870 (0.4)
Migraine 78,530 (7.9) 39,162 (7.9) 27,765 (2.9) 13,706 (2.9)
Corticosteroid use 13,887 (1.4) 6787 (1.4) 7833 (0.8) 3991 (0.8)
HIV/AIDS 206 (0.0) 83 (0.0) 264 (0.0) 181 (0.0)
Systemic lupus erythematosus 1149 (0.1) 576 (0.1) 108 (0.0) 57 (0.0)
Atypical antipsychotic use 5663 (0.6) 2806 (0.6) 5511 (0.6) 2825 (0.6)
Severe mental illness 73,909 (7.5) 36,890 (7.5) 38,202 (4.0) 19,062 (4.0)
Erectile dysfunction diagnosis or treatment NA (NA) NA (NA) 26,099 (2.8) 13,165 (2.8)
Charlson comorbidity index score
 0 791,395 (80.0) 396,570 (80.1) 781,665 (82.6) 391,400 (82.7)
 1 153,590 (15.5) 76,061 (15.4) 134,497 (14.2) 66,703 (14.1)
 2 34,250 (3.5) 17,045 (3.4) 23,133 (2.4) 11,532 (2.4)
 3+ 10,497 (1.1) 5189 (1.0) 7489 (0.8) 3757 (0.8)
  1. Mean (SD) or number (%)