Table 1 Clinical parameters associated with the patients whose biopsies were analysed with dual RNA-seq and used to build the host-pathogen interactome in NSTI
Monomicrobial NSTI | Polymicrobial NSTI | |
|---|---|---|
Age (years) | 57 (44–61) | 55 (46.5–64) |
Sex | ||
Female/male (%) | 12 (34.3%)/ 23 (65.7%) | 9 (39.2%)/ 14 (60.8%) |
Outcome | ||
Mortality 30 days (%) | 1 (2.86%) | 4 (17.4%) |
Mortality 90 days (%) | 3 (8.57%) | 4 (17.4%) |
Mortality 365 days (%) | 6 (17.14%) | 6 (26.1%) |
Hospital | ||
Righospitalet Copenhagen | 13 (15)/35 (42) | 11 (11)/ 24 (25) |
Karolinska University Hospital | 7 (8)/35 (42) | 8 (8)/ 24 (25) |
Sahlgrenska University Hospital | 5 (6)/35 (42) | 2 (2)/ 24 (25) |
University of Bergen | 10 (13) /35 (42) | 2 (3)/ 24 (25) |
Laboratory values | ||
Haemoglobin (g/dl) | 10.5 (2.51–11.76) | 8.8 (7.9–10.55) |
White blood cells (10^9/l) | 13.4 (11.15–16.625) | 12.3 (8.7–15.7) |
C-reactive protein (mg/l) | 207 (152–293.25) | 293 (140–343) |
Creatinine (μmol/l) | 123 (87.75–233.75) | 116.5 (81.25–180.75) |
SOFA score | 9 (5–11) | 8 (6–11) |
SAPS II | 40 (35–51) | 40.5 (29–48) |
Location of infection in patients | ||
Head and neck (%) | 7 (20%) | 9 (39.1%) |
Upper extremities including thoracic involvement (%) | 14 (40%) | 3 (13%) |
Abdomen and ano-genital area (%) | 5 (14.3%) | 12 (52.2%) |
Lower extremities (%) | 15 (42.9%) | 5 (21.7%) |