Fig. 3

Relationship among IL-6 expression, PD-L1 expression, and immune cell infiltration in patients with NSCLC. A, B IHC analysis of PD-L1 expression (A) and CD8⁺ TIL infiltration (B) according to IL-6 expression levels in tumor tissues of patients with NSCLC. C IHC analysis of the TIME based on PD-L1 expression and CD8⁺ TIL infiltration according to IL-6 expression levels in tumor tissues of patients with NSCLC. D–F Correlogram based on Pearson’s r values of IL-6 expression, PD-L1 expression, and four tumor-infiltrated immune cell types in tumor tissues of patients with NSCLC (D), patients with LUAD (E), and patients with LUSC (F). G–I IHC analysis of M2 macrophages (G), Treg cells (H), and MDSCs (I) according to IL-6 expression levels in tumor tissues of patients with NSCLC. J Representative IHC images show the correlation of IL-6 expression, PD-L1 expression, and four tumor-infiltrated immune cell types in NSCLC samples. Scale bar = 20 μm