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Table 2 Multivariable Mendelian randomization (MR) analysis for the associations of circulating vitamin E with the risk of bladder cancer and breast cancer

From: Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study

Corrected trait Bladder cancer Breast cancer
Betaa 95% CIa Pa Betaa 95% CIa Pa
E70-E90 metabolic disorders 3.03 0.69, 5.37 0.011 −0.18 −0.73, 0.36 0.507
E78 disorders of lipoprotein metabolism and other lipidemias 2.96 0.91, 5.01 4.70×10-3 −0.23 −0.70, 0.25 0.349
Eosinophill count 2.61 1.15, 4.07 4.53×10-4 −0.36 −0.71, −0.01 0.043
Eosinophill percentage 2.34 1.02, 3.66 5.28×10-4 −0.37 −0.69, −0.05 0.022
High cholesterol 2.99 1.16, 4.83 1.38×10-3 −0.28 −0.71, 0.15 0.204
High light scatter reticulocyte count 3.07 1.26, 4.89 8.93×10-4 −0.30 −0.73, 0.13 0.165
High light scatter reticulocyte percentage 2.94 1.22, 4.65 7.85×10-4 −0.31 −0.71, 0.10 0.137
I20-I25 ischemic heart diseases 1.58 −0.15, 3.32 0.073 −0.26 −0.66, 0.15 0.211
I25 chronic ischemic heart disease 1.62 −0.28, 3.51 0.095 −0.23 −0.67, 0.21 0.308
Lymphocyte count 1.29 −0.15, 2.74 0.080 −0.34 −0.67, −0.01 0.046
Mean corpuscular hemoglobin 1.13 −0.70, 2.95 0.225 −0.28 −0.70, 0.15 0.202
Mean corpuscular hemoglobin concentration 2.67 1.17, 4.17 4.67×10-4 −0.35 −0.71, 0.01 0.057
Mean corpuscular volume 2.83 0.34, 5.32 0.026 −0.15 −0.73, 0.43 0.607
Mean platelet (thrombocyte) volume 2.66 1.05, 4.27 1.18×10-3 −0.29 −0.67, 0.08 0.126
Mean reticulocyte volume 3.09 1.19, 4.98 1.42×10-3 −0.28 −0.72, 0.17 0.223
Mean sphered cell volume 3.14 1.04, 5.23 3.29×10-3 −0.24 −0.72, 0.25 0.341
Monocyte count 1.81 0.60, 3.02 3.40×10-3 −0.38 −0.67, −0.10 0.008
Monocyte percentage 1.47 0.19, 2.74 0.025 −0.38 −0.67, −0.08 0.012
Platelet count 2.74 1.14, 4.34 7.81×10-4 −0.31 −0.69, 0.07 0.109
Platelet crit 2.71 1.17, 4.25 5.70×10-4 −0.33 −0.69, 0.04 0.080
Platelet distribution width 2.81 1.18, 4.43 7.21×10-4 −0.31 −0.70, 0.07 0.112
Red blood cell (erythrocyte) distribution width 2.51 1.09, 3.94 5.43×10-4 −0.34 −0.67, 0.00 0.051
Reticulocyte count 3.15 1.25, 5.05 1.17×10-3 −0.29 −0.74, 0.16 0.207
Reticulocyte percentage 3.01 1.23, 4.79 9.32×10-4 −0.30 −0.72, 0.12 0.164
  1. aMultivariable inverse variance weighting (IVW) method