Table 2 Multivariable Mendelian randomization (MR) analysis for the associations of circulating vitamin E with the risk of bladder cancer and breast cancer

E70-E90 metabolic disorders

3.03

0.69, 5.37

0.011

−0.18

−0.73, 0.36

0.507

E78 disorders of lipoprotein metabolism and other lipidemias

2.96

0.91, 5.01

4.70×10^-3

−0.23

−0.70, 0.25

0.349

Eosinophill count

2.61

1.15, 4.07

4.53×10^-4

−0.36

−0.71, −0.01

0.043

Eosinophill percentage

2.34

1.02, 3.66

5.28×10^-4

−0.37

−0.69, −0.05

0.022

High cholesterol

2.99

1.16, 4.83

1.38×10^-3

−0.28

−0.71, 0.15

0.204

High light scatter reticulocyte count

3.07

1.26, 4.89

8.93×10^-4

−0.30

−0.73, 0.13

0.165

High light scatter reticulocyte percentage

2.94

1.22, 4.65

7.85×10^-4

−0.31

−0.71, 0.10

0.137

I20-I25 ischemic heart diseases

1.58

−0.15, 3.32

0.073

−0.26

−0.66, 0.15

0.211

I25 chronic ischemic heart disease

1.62

−0.28, 3.51

0.095

−0.23

−0.67, 0.21

0.308

Lymphocyte count

1.29

−0.15, 2.74

0.080

−0.34

−0.67, −0.01

0.046

Mean corpuscular hemoglobin

1.13

−0.70, 2.95

0.225

−0.28

−0.70, 0.15

0.202

Mean corpuscular hemoglobin concentration

2.67

1.17, 4.17

4.67×10^-4

−0.35

−0.71, 0.01

0.057

Mean corpuscular volume

2.83

0.34, 5.32

0.026

−0.15

−0.73, 0.43

0.607

Mean platelet (thrombocyte) volume

2.66

1.05, 4.27

1.18×10^-3

−0.29

−0.67, 0.08

0.126

Mean reticulocyte volume

3.09

1.19, 4.98

1.42×10^-3

−0.28

−0.72, 0.17

0.223

Mean sphered cell volume

3.14

1.04, 5.23

3.29×10^-3

−0.24

−0.72, 0.25

0.341

Monocyte count

1.81

0.60, 3.02

3.40×10^-3

−0.38

−0.67, −0.10

0.008

Monocyte percentage

1.47

0.19, 2.74

0.025

−0.38

−0.67, −0.08

0.012

Platelet count

2.74

1.14, 4.34

7.81×10^-4

−0.31

−0.69, 0.07

0.109

Platelet crit

2.71

1.17, 4.25

5.70×10^-4

−0.33

−0.69, 0.04

0.080

Platelet distribution width

2.81

1.18, 4.43

7.21×10^-4

−0.31

−0.70, 0.07

0.112

Red blood cell (erythrocyte) distribution width

2.51

1.09, 3.94

5.43×10^-4

−0.34

−0.67, 0.00

0.051

Reticulocyte count

3.15

1.25, 5.05

1.17×10^-3

−0.29

−0.74, 0.16

0.207

Reticulocyte percentage

3.01

1.23, 4.79

9.32×10^-4

−0.30

−0.72, 0.12

0.164