Fig. 6

Effect of intraperitoneal administration of EZH2 inhibitor on fetoplacental weights in the mouse. A Time-line illustrating experimental procedures in pregnant mice. i.p., intraperitoneal injection. B–G Administration of EZH2 inhibitor EPZ005687 (EPZ) (8 mg/kg BW) increased the average fetal (B) and placental (C) weights per litter (control, n = 9 dams; EPZ, n = 8 dams) as well as the fetal (D and F) and placental (E and G) weights of each sex. Female fetuses: control group, n = 32; EPZ group, n = 29; male fetuses: control group, n = 31; EPZ group, n = 24. Data are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs control group