Table 2 Association between BMI trajectories and NSCLC risk stratified by the four susceptibility SNPs

rs79297227

1.01×10⁻⁷

 TT

  NSCLC/Non-NSCLC

402/2947

481/5593

111/1772

14/268

  HR (95% CI)^a

Reference

0.75 (0.65, 0.85)

0.53 (0.42, 0.67)

0.42 (0.24, 0.74)

0.74 (0.67, 0.81)

3.37×10⁻¹⁰

 TC/CC

  NSCLC/Non-NSCLC

30/353

39/583

34/199

4/29

  HR (95% CI)^a

Reference

1.06 (0.62, 1.81)

2.54 (1.42, 4.53)

1.73 (0.49, 6.05)

1.49 (1.14, 1.94)

0.003

rs2336652

3.92×10⁻⁷

 CC

  NSCLC/Non-NSCLC

408/3031

465/5692

115/1810

13/282

  HR (95% CI)^a

Reference

0.72 (0.63, 0.84)

0.54 (0.43, 0.68)

0.34 (0.18, 0.62)

0.73 (0.66, 0.80)

6.51×10⁻¹¹

 CA/AA

  NSCLC/Non-NSCLC

40/398

64/734

32/229

4/31

  HR (95% CI)^a

Reference

0.98 (0.64, 1.51)

1.85 (1.09, 3.12)

2.05 (0.69, 6.10)

1.33 (1.04, 1.70)

0.025

rs16018

3.92×10⁻⁷

 AA

  NSCLC/Non-NSCLC

252/1645

233/3103

63/983

4/153

  HR (95% CI)^a

Reference

0.58 (0.48, 0.70)

0.49 (0.36, 0.66)

0.12 (0.03, 0.47)

0.64 (0.56, 0.73)

8.56×10⁻¹¹

 AG/GG

  NSCLC/Non-NSCLC

197/1789

299/3328

84/1058

14/160

  HR (95% CI)^a

Reference

0.94 (0.78, 1.14)

0.81 (0.62, 1.08)

0.87 (0.50, 1.52)

0.92 (0.82, 1.04)

0.187

rs4726760

9.19×10⁻⁷

 CC

  NSCLC/Non-NSCLC

308/2528

412/4656

121/1433

16/235

  HR (95% CI)^a

Reference

0.88 (0.76, 1.04)

0.86 (0.69, 1.09)

0.57 (0.33, 0.98)

0.90 (0.81, 0.99)

0.030

 CT/TT

  NSCLC/Non-NSCLC

126/811

110/1589

23/522

1/68

  HR (95% CI)^a

Reference

0.47 (0.35, 0.62)

0.24 (0.14, 0.40)

0.13 (0.02, 0.95)

0.48 (0.39, 0.59)

2.07×10⁻¹¹