Table 2 Overview of the simulation scenarios. Parameter values for the baseline reactive vaccination scenario for each pathogen. Outbreak response threshold cases and threshold window refer to the number of cases that need to occur within a certain time window to trigger an outbreak response. Parameter values in parentheses are alternative values used as a part of the sensitivity analysis
From: Projecting vaccine demand and impact for emerging zoonotic pathogens
Parameter | LASV, MERS-CoV | NiV, RVFV |
|---|---|---|
Outbreak response | ||
 Threshold cases | 10 (5) | 3 (1, 5) |
 Threshold window | 28 days | 28 days |
 Delay | 28 days (7, 120) | 28 days (7, 120) |
Vaccination | ||
 Coverage HCWa | 70% (80, 50, 90) | |
 Coverage population | 70% (20, 50, 90) | |
 Delay between doses | 28 days | |
 Regimens per index case (ring vaccination only) | 90 | |
Per-exposure protection (PEP) | ||
 Single dose | 70% (50%, 90%) | |
 Two doses, 1st | 35% (25%, 45%) | |
 Two doses, 2nd | 70% (50%, 90%) | |
 Delay | 7 days (14) | |