Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes

Table 2 Risk genes verified by Mendelian randomization (MR) and colocalization using brain pQTL

	Gene	Beta	SE	P value	Evidence for replication	H₄	PP4/(PP3+PP4)	Causal variant
1	CAND2	−0.758	0.176	1.71E−05	Yes	0.94	0.99	Yes
2	ICA1L	−2.531	0.493	2.81E−07	Yes	0.99	0.99	Yes
3	ALDH2	1.157	0.314	2.28E−04	Yes	0.75	0.92	Yes
4	MADD	1.161	0.398	3.53E−03	Yes	-	-	-

This table shows the Beta, SE, and P values for the MR. MR P values and a direction of effect consistent with the discovery and replication PWAS results. For the 4 FDR-significant genes in the discovery lacunar stroke PWAS, the result of COLOC H₄, which is the Bayesian posterior probability that a genetic variant is shared by both traits (that is, the genetically regulated protein level and lacunar stroke)

ISSN: 1741-7015