| |
Gene
|
Beta
|
SE
|
P value
|
Evidence for replication
|
H4
|
PP4/(PP3+PP4)
|
Causal variant
|
|---|
|
1
|
CAND2
|
−0.758
|
0.176
|
1.71E−05
|
Yes
|
0.94
|
0.99
|
Yes
|
|
2
|
ICA1L
|
−2.531
|
0.493
|
2.81E−07
|
Yes
|
0.99
|
0.99
|
Yes
|
|
3
|
ALDH2
|
1.157
|
0.314
|
2.28E−04
|
Yes
|
0.75
|
0.92
|
Yes
|
|
4
|
MADD
|
1.161
|
0.398
|
3.53E−03
|
Yes
|
-
|
-
|
-
|
- This table shows the Beta, SE, and P values for the MR. MR P values and a direction of effect consistent with the discovery and replication PWAS results. For the 4 FDR-significant genes in the discovery lacunar stroke PWAS, the result of COLOC H4, which is the Bayesian posterior probability that a genetic variant is shared by both traits (that is, the genetically regulated protein level and lacunar stroke)
