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Fig. 7 | BMC Medicine

Fig. 7

From: A novel CREB5/TOP1MT axis confers cisplatin resistance through inhibiting mitochondrial apoptosis in head and neck squamous cell carcinoma

Fig. 7

A positive correlation between CREB5 and TOP1MT expression was observed in HNSCC tissues. A CREB5 and TOP1MT expression was detected using IHC in normal oral tissues. B Representative images of CREB5 and TOP1MT expression in HNSCC tissues. C The expression scores of CREB5 and TOP1MT were analyzed in normal and HNSCC tissues. D IHC analysis of the correlation between CREB5 and TOP1MT expression in the HNSCC tissue microarray. E–H The correlations between the expression scores of TOP1MT and CREB5 and gender, grade, TNM stage, and age were analyzed in normal and HNSCC tissues. I The proposed model illustrates the regulatory role of TOP1MT and CREB5 in promoting cisplatin resistance in HNSCC. *p < 0.05; **p < 0.01; ***p < 0.001

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BMC Medicine

ISSN: 1741-7015

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