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Table 6 Clinical parameters and laboratory measures associated with the occurrence of rheumatoid arthritis

From: A positive faecal immunochemical test result and its association with the incidence of rheumatoid arthritis, systemic lupus erythematosus, and psoriatic arthritis: an analysis of one-million national colorectal cancer screening programme results

 

Univariable analysis

Multivariable analysis

HR (95% CI)

p value

HR (95% CI)

p value

FIT result

 Positive

1.15 (1.08, 1.22)

<0.001

1.16 (1.09, 1.24)

<0.001

 Negative

Ref.

 

Ref.

 

Sex

 Male

Ref.

 

Ref.

 

 Female

2.19 (2.07, 2.31)

<0.001

2.15 (2.01, 2.29)

<0.001

Age group at screening, years

 50–54

1.24 (1.14, 1.35)

<0.001

1.23 (1.13, 1.34)

<0.001

 55–59

1.19 (1.08, 1.30)

<0.001

1.22 (1.11, 1.34)

<0.001

 60–64

1.26 (1.15, 1.37)

<0.001

1.28 (1.18, 1.40)

<0.001

 65–69

1.25 (1.13, 1.38)

<0.001

1.29 (1.17, 1.42)

<0.001

 ≥70

Ref.

 

Ref.

 

BMI

1.00 (0.99, 1.01)

0.664

1.00 (0.99, 1.01)

0.750

Smoking status

 No

Ref.

 

Ref.

 

 Yes

0.67 (0.62, 0.73)

<0.001

1.04 (0.94, 1.14)

0.460

Alcohol drinking

 No

Ref.

 

Ref.

 

 Yes

0.61 (0.57, 0.66)

<0.001

0.87 (0.80, 0.95)

0.001

Exercise

 No

1.05 (1, 10.12)

0.068

1.02 (0.97, 1.08)

0.444

 Yes

Ref.

 

Ref.

 

Insurance type

    

 Medial aid

Ref.

 

Ref.

 

 NHI

0.98 (0.69, 1.38)

0.890

1.06 (0.75, 1.49)

0.744

Hypertension

 No

Ref.

 

Ref.

 

 Yes

0.92 (0.84, 1.01)

0.070

0.98 (0.9, 1.08)

0.683

Diabetes

 No

Ref.

 

Ref.

 

 Yes

0.79 (0.69, 0.89)

<0.001

0.89 (0.78, 1.01)

0.076

Dyslipidaemia

 No

Ref.

 

Ref.

 

 Yes

0.95 (0.89, 1.00)

0.068

1.00 (0.91, 1.10)

0.975

Blood haemoglobin <13 g/dL for male and <12 g/dL for female

 No

Ref.

 

Ref.

 

 Yes

1.62 (1.19, 2.21)

0.002

1.14 (0.84, 1.55)

0.406

Serum creatinine > 1.5 mg/dL

 No

Ref.

 

Ref.

 

 Yes

0.92 (0.73, 1.16)

0.480

1.08 (0.86, 1.36)

0.515

Serum total cholesterol ≥ 200 mg/dL

 No

Ref.

 

Ref.

 

 Yes

1.03 (0.96, 1.10)

0.404

0.96 (0.86, 1.06)

0.386

Serum triglyceride ≥ 150 mg/dL

 No

Ref.

 

Ref.

 

 Yes

0.85 (0.79, 0.92)

<0.001

0.93 (0.84, 1.02)

0.129

Serum HDL-cholesterol < 60 mg/dL

 No

Ref.

 

Ref.

 

 Yes

0.95 (0.88, 1.03)

0.248

1.10 (1.01, 1.21)

0.031

Serum LDL-cholesterol ≥130 mg/dL

 No

Ref.

 

Ref.

 

 Yes

1.04 (0.97, 1.11)

0.276

0.95 (0.86, 1.06)

0.384

  1. HR hazard ratio, CI confidence interval, FIT faecal immunochemical test, BMI body mass index, NHI national health insurance, HDL high-density lipoprotein, LDL low-density lipoprotein
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