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Fig. 2 | BMC Medicine

Fig. 2

From: DNA methylation subtypes guiding prognostic assessment and linking to responses the DNA methyltransferase inhibitor SGI-110 in urothelial carcinoma

Fig. 2

WGBS analysis reveals that the DNA methylation profiles of UTUC and UCB are similar. A Global changes in average 5mC levels in different genomic elements determined by WGBS (the promoter is defined as ±1000 bp of the TSS) in UCB (n = 9), UTUC (n = 36), and paired adjacent urothelium specimens (n = 4). B Distribution of the average methylation levels of all genome-wide 10-kb bins in paired UTUC tumors and adjacent urothelium (n = 4). C Density plot of average DNA methylation within all genome-wide 10-kb bins in UCB (n = 9) and UTUC (n = 36) tumor samples. D Box plot of the correlation of the average methylation level within all genome-wide 10-kb bins within and between the two groups. E Graphical representation of the dynamic 5mC pattern of a region from chromosome 1. Two normal urothelium samples, UTUC tumor tissues and UCB tumor tissues were randomly selected

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BMC Medicine

ISSN: 1741-7015

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