Fig. 1
Temporal and developmental alterations to the circulatory lipids in the GUSTO cohort: A Antenatal and postnatal plasma collection time points for mother-offspring dyads in GUSTO cohort. B PCA plot of lipidomics data (n=2491). C Postnatal vs. antenatal changes in maternal lipidomic profiles. D Comparison of maternal antenatal plasma with cord blood (CB) lipidomic profiles. E Changes in child lipidomic profiles between birth and 6 years of age. F Comparison of pediatric (6-year-old child) and adult (postnatal mothers) plasma lipidomes. The most significant lipid species based on adjusted p-values are labeled in c-f. Effect size is shown as log2 of fold change. Error bars indicate 95% confidence interval. Diamond—Padj ≥ 0.05 or |FC|≤1.5 (gray), circle—Padj <0.05 and |FC|>1.5, and square—Padj <1.00E−10 and |FC|>1.5