Weight loss-induced improvement of body weight and insulin sensitivity is not amplified by a subsequent 12-month weight maintenance intervention but is predicted by adaption of adipose atrial natriuretic peptide system: 48-month results of a randomized controlled trial

Table 1 Metabolic and anthropometric parameters of the randomized participants after weight loss. Results were presented as median and IQR or mean±SD, and n represents the number of participants

Parameter	n	Intervention group	n	Control group	p value
Age [year]	72	50.3 [41.6, 60.4]	71	51.3 [43.8, 61.4]	0.195
BMI [kg/m²]	72	31.2 [28.5, 35.3]	71	31.3 [28.8, 37.4]	0.462
Use of diuretics [n]		8		7
Waist circumference [cm]	72	96.5 [88.1, 105.9]	71	99.0 [88.0, 110.0]	0.292
Total cholesterol [mg/dl]	72	175.7±36.7	71	171.9±32.7	0.513
HDL-cholesterol [mg/dl]	72	46.6 [39.2, 56.1]	71	47.4 [39.0, 57.5]	0.905
LDL-cholesterol [mg/dl]	71	109.2±31.1	71	103.3±29.6	0.244
Triacylglycerol [mg/dl]	72	77.0 [59.5, 105.0]	71	88.7 [68.4, 128.0]	0.020
ISI_Clamp [mg kg⁻¹ min⁻¹/[mU l⁻¹]]	71	0.08 [0.07, 0.11]	69	0.08 [0.06, 0.10]	0.587
Systolic blood pressure [mmHg]	71	119.0 [113.0, 126.3]	71	119.0 [110.0, 126.7]	0.587
Diastolic blood pressure [mmHg]	71	74.3 [69.0, 81.7]	71	71.7 [68.0, 79.3]	0.242
Adipose NPR-A mRNA expression	44	4785 [4328, 5327]	31	4786 [4393, 5540]	0.889
Adipose NPR-C mRNA expression	44	456 [279, 629]	31	528 [279, 1004]	0.241

BMI body mass index, HDL-cholesterol high-density lipoprotein cholesterol, LDL-cholesterol low-density lipoprotein cholesterol, ISI_Clamp Insulin sensitivity index assessed by hyperinsulinemic euglycemic clamp, NPR natriuretic receptor

ISSN: 1741-7015