Fig. 3

Changes in cholesterol metabolism pathway proteins after drug treatment. a Proteomic data were analyzed by volcano plots, with the x-axis representing the log₂ (FC) (sample/control), and the y-axis representing the − log₁₀ P value. Red dots indicate significantly different proteins regulated by SOAT1-targeted compounds; gray, blue, and green dots indicate proteins that are meaningless or poor qualitative data. Significant proteins are marked by boxes. b Gene Ontology (GO) analyzes the biological process, cellular component, and molecular function of the dysregulated proteins. P values were corrected by the Benjamini-Hochberg (BH) algorithm and significant calls were made based on a BH adjusted P value < 0.01. c The cluster heat map of the dysregulated cholesterol metabolism proteins after treatment with SOAT1-targeted compounds. d Biological insight into the cholesterol metabolism reprogramming after treatment with SOAT1-targeted compounds. The alteration score of each protein is depicted as log ratios (fold change, expressed as log2 (ratio of average protein abundance in each treatment proteomic results versus the control group)). Rectangular color bars indicate upregulated and downregulated proteins