Fig. 4

Changes in cholesterol synthesis precursors and metabolic derivatives after drug treatment. a The metabolome data were analyzed by volcano plots, with the x-axis representing the log2 (FC) (sample/control), and the y-axis representing the − log₁₀ P value. Red dots indicate significantly different metabolites regulated by SOAT1-targeted compound; gray, blue, and green dots indicate proteins that are meaningless or poor qualitative data. b Changes in cholesterol metabolites in hepatocelluar carcinoma cell lines after treatment with SOAT1-targeted compounds. The alteration score of each metabolite is depicted as log ratios (fold change, expressed as log₂ (ratio of metabolite abundance in each treatment proteomics versus the control group)) (P < 0.01). c Representative metabolite changes in the cholesterol metabolism signaling pathway after treatment with SOAT1-targeted compounds (n = 6). Graphs show mean ± SD. P values were calculated by the two-sided log-rank test