Fig. 7From: High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growthAntitumor mechanism of SOAT1-targeting compounds. Compounds that target SOAT1 protein reprogram tumor cholesterol metabolism, specifically blocking the production of cholesterol ester, inhibiting cholesterol synthesis and transportation, and activating conversion. These compounds also simultaneously enhance immune cells to inhibit tumor growthBack to article page