Fig. 5

No impact of H1N1Ag or PfAg on SARS-CoV-2-reactive CD4⁺ T cells in COVID-19 patients. Dot plots are representative of the frequencies of double positive CD4⁺ T cells, expressing CD69 and CD137 after incubation in culture medium (A), with SPP (B), H1N1Ag (C), PfAg (D), alone or SPP in combination with H1N1Ag (E), and PfAg (F). Graphs summarize the frequencies of CD69⁺, CD137⁺ in CD4⁺ T cell populations in the different settings in the presence or absence of PfAg (G) or H1N1Ag (H). Each symbol represents individual donors. Bars indicate Means ± SEM of the percentage of SARS-CoV-2-reactive T cells in each setting. Data were obtained from 15 COVID-19 patients