Table 1 Baseline characteristics of the UK Biobank participants included in our analyses stratified by the median IL-6R-mediated signaling genetic score
Variable | IL-6R-mediated signaling GRS < median | IL-6R-mediated signaling GRS > median | p-value | ||
|---|---|---|---|---|---|
Age, years | 59 | 51–64 | 59 | 51–64 | 0.983 |
Sex, females | 114,383 | 52.8 | 114,563 | 52.9 | 0.585 |
CRP, mg/dL | 1.28 | 0.63–2.66 | 1.45 | 0.71–2.98 |  < 2.2 × 10−16 |
SBP, mmHg | 137 | 126–151 | 137 | 126–151 | 0.218 |
DBP, mmHg | 77 | 84–92 | 77 | 84–92 | 0.755 |
BMI, kg/m2 | 26.8 | 24.2–30.0 | 26.8 | 24.2–30.0 | 0.847 |
eGFR, mL/min/1.73 m2 | 88.3 | 76.5–100.1 | 88.2 | 76.3–100.0 | 0.062 |
HbA1c, % | 5.36 | 5.15–5.61 | 5.38 | 5.15–5.62 | 4.1 × 10−07 |
LDL-cholesterol, mg/dL | 136.5 | 114.1–159.9 | 136.3 | 113.8–159.8 | 0.038 |
HDL-cholesterol, mg/dL | 53.9 | 45.1–64.6 | 53.8 | 45.1–64.5 | 0.131 |
Lipid-lowering drug use | 37,296 | 17.2 | 37,742 | 17.4 | 0.044 |
Antidiabetic drug use | 6,632 | 3.0 | 6,913 | 3.2 | 0.014 |
Antihypertensive drug use | 47,587 | 22.0 | 47,615 | 22.0 | 0.920 |