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Table 1 Baseline characteristics of the UK Biobank participants included in our analyses stratified by the median IL-6R-mediated signaling genetic score

From: Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups

Variable IL-6R-mediated signaling GRS < median IL-6R-mediated signaling GRS > median p-value
Age, years 59 51–64 59 51–64 0.983
Sex, females 114,383 52.8 114,563 52.9 0.585
CRP, mg/dL 1.28 0.63–2.66 1.45 0.71–2.98  < 2.2 × 10−16
SBP, mmHg 137 126–151 137 126–151 0.218
DBP, mmHg 77 84–92 77 84–92 0.755
BMI, kg/m2 26.8 24.2–30.0 26.8 24.2–30.0 0.847
eGFR, mL/min/1.73 m2 88.3 76.5–100.1 88.2 76.3–100.0 0.062
HbA1c, % 5.36 5.15–5.61 5.38 5.15–5.62 4.1 × 10−07
LDL-cholesterol, mg/dL 136.5 114.1–159.9 136.3 113.8–159.8 0.038
HDL-cholesterol, mg/dL 53.9 45.1–64.6 53.8 45.1–64.5 0.131
Lipid-lowering drug use 37,296 17.2 37,742 17.4 0.044
Antidiabetic drug use 6,632 3.0 6,913 3.2 0.014
Antihypertensive drug use 47,587 22.0 47,615 22.0 0.920
  1. The results represent median (interquartile range) or N (%). The p-values are derived from the Mann–Whitney U test for quantitative variables and the chi-square test for binary variables and test the null hypothesis that there is no difference in the listed phenotype by median IL6R signaling genetic risk score (GRS)