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Table 3 Significant association between phenotypic and genetically determined height with eight traits

From: Your height affects your health: genetic determinants and health-related outcomes in Taiwan

Height (exposure)

8 traits (outcome)

Beta

95% confidence interval

P-value

 

Anthropometric trait 1

    

Height (Phenotype)

Body weight (Phenotype)

4.162

4.083

4.241

0.00E+00

Height (PRS)

Body weight (Phenotype)

1.218

1.141

1.296

7.81E−206

Height (Phenotype)

Waist circumference (Phenotype)

1.363

1.287

1.440

1.56E−264

Height (PRS)

Waist circumference (Phenotype)

0.446

0.375

0.517

5.81E−35

Height (Phenotype)

Hip circumference (Phenotype)

1.845

1.790

1.900

0.00E+00

Height (PRS)

Hip circumference (Phenotype)

0.601

0.549

0.652

4.53E−114

 

Anthropometric trait 2

    

Height (Phenotype)

Body mass index (Phenotype)

−0.192

−0.222

−0.162

1.36E−36

Height (PRS)

Body mass index (Phenotype)

−0.084

−0.111

-0.056

2.01E−09

Height (Phenotype)

Waist-hip ratio (Phenotype)

−0.003

−0.003

−0.002

1.75E−24

Height (PRS)

Waist-hip ratio (Phenotype)

−0.001

−0.001

0.000

7.18E−04

Height (Phenotype)

Body fat (Phenotype)

−0.335

−0.385

−0.286

3.82E−40

Height (PRS)

Body fat (Phenotype)

−0.140

−0.186

−0.095

1.58E−09

 

Blood pressure, lipids, and glucose trait

    

Height (Phenotype)

Total cholesterol (Phenotype)

−1.117

−1.407

−0.828

4.13E−14

Height (PRS)

Total cholesterol (Phenotype)

−0.587

−0.853

−0.321

1.55E−05

Height (Phenotype)

Low-density lipoprotein cholesterol (Phenotype)

−1.180

−1.439

−0.921

4.68E−19

Height (PRS)

Low-density lipoprotein cholesterol (Phenotype)

−0.629

−0.867

−0.391

2.25E−07

  1. PRS polygenic risk score
  2. Height phenotype indicates the measured height (normalized using Z-scores)
  3. Height polygenic risk score (PRS) indicates the height calculated from 251 SNPs (Tables 1 and 2)
  4. Multivariate linear regression analysis was used with adjustment factors (age, sex, educational attainment, drinking, smoking, regular exercise, and 10 principal components analysis data). P-value (p < 0.05/(14+49)) was highlighted in bold italic. P-value less than 2.23E−308 were expressed as 0.00E+00