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Table 3 Sensitivity analysis regarding the risk of IBS according to Quartiles of baseline fatty liver index

From: Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study

FLI Quartiles No. of IBS No. of participants Adjusted HR (95%CI) P value P for trend
Sensitivity analysis 1: excluding IBS participants diagnosed within 1 year after baseline (N = 396,184)
 Quartile 1 1691 98,180 Reference    < 0.001
 Quartile 2 1659 99,151 1.15 (1.08–1.24)  < 0.001
 Quartile 3 1552 99,565 1.19 (1.11–1.28)  < 0.001
 Quartile 4 1573 99,288 1.21 (1.12–1.31)  < 0.001
Sensitivity analysis 2: excluding IBS participants diagnosed within 2 years after baseline (N = 395,546)  
 Quartile 1 1509 97,998 Reference   
 Quartile 2 1495 98,987 1.16 (1.08–1.25)  < 0.001  < 0.001
 Quartile 3 1405 99,418 1.20 (1.11–1.30)  < 0.001  
 Quartile 4 1428 99,143 1.22 (1.13–1.32)  < 0.001  
Sensitivity analysis 3: excluding incident alcoholic liver disease participants after baseline (N = 395,775)
 Quartile 1 1878 98,306 Reference   
 Quartile 2 1793 99,161 1.12 (1.05–1.20) 0.001  < 0.001
 Quartile 3 1696 99,496 1.18 (1.10–1.26)  < 0.001  
 Quartile 4 1737 98,812 1.21 (1.13–1.30)  < 0.001  
Sensitivity analysis 4: competing risk model (N = 396,838, No. of competing events = 24,742)  
 Quartile 1 1882 98,371 Reference   
 Quartile 2 1797 99,289 1.13 (1.05–1.20) 0.001  < 0.001
 Quartile 3 1701 99,714 1.18 (1.10–1.26)  < 0.001  
 Quartile 4 1749 99,464 1.21 (1.12–1.30)  < 0.001  
Sensitivity analysis 5: excluding HBV or HCV antigen-positive participants after baseline (N = 396,613)
 Quartile 1 1877 98,310 Reference   
 Quartile 2 1796 99,235 1.13 (1.05, 1.20)  < 0.001  < 0.001
 Quartile 3 1701 99,665 1.18 (1.10, 1.26)  < 0.001  
 Quartile 4 1749 99,403 1.21 (1.13, 1.30)  < 0.001  
Sensitivity analysis 6: additionally adjusted psychologic disorder including depression and anxiety (N = 396,838)
 Quartile 1 1882 98,371 Reference   
 Quartile 2 1797 99,289 1.11 (1.03–1.18) 0.003  < 0.001
 Quartile 3 1701 99,714 1.14 (1.07–1.23)  < 0.001  
 Quartile 4 1749 99,464 1.16 (1.08–1.24)  < 0.001  
  1. Note: All adjusted HRs were calculated by adjusting the following covariates: age, gender, Townsend deprivation index, education level, ethnicity, smoking status, alcohol drinking, IPAQ (International Physical Activity Questionnaire) and type 2 diabetes. P for trend was calculated by using the median value of each fatty liver index Quartile (10.5, 32.2, 61.2, and 88.6 for sensitivity analysis 1, 2, 4, 5, and 6; 10.5, 32.2, 61.2, and 88.5 for sensitivity analysis 3)
  2. IBS irritable bowel syndrome, HR hazard ratio, CI confidence interval