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Table 3 Area under the receiver operating characteristic for predicting 28-day mortality in the original, modified, and vasopressor only cardiovascular/total SOFA

From: Modified cardiovascular SOFA score in sepsis: development and internal and external validation

  Original model Modified model Vasopressor only model pa pb
AUROC (95% CI) of cardiovascular SOFA
 Derivation cohort 0.624
(0.596–0.652)
0.682
(0.654–0.709)
0.625
(0.597–0.653)
 < 0.001 0.125
 Internal validation 0.638
(0.596–0.680)
0.716
(0.678–0.754)
0.640
(0.598–0.683)
 < 0.001 0.023
 External validation 1 0.557
(0.536–0.579)
0.648
(0.627–0.669)
0.610
(0.587–0.632)
 < 0.001  < 0.001
 External validation 2 0.589
(0.565–0.612)
0.674
(0.650–0.700)
0.635
(0.610–0.660)
 < 0.001  < 0.001
AUROC (95% CI) of total SOFA
 Derivation cohort 0.750
(0.725–0.776)
0.762
(0.738–0.787)
0.751
(0.725–0.776)
 < 0.001 0.682
 Internal validation 0.773
(0.736–0.810)
0.787
(0.751–0.822)
0.774
(0.738–0.811)
0.001 0.495
 External validation 1 0.678
(0.658–0.699)
0.712
(0.693–0.732)
0.704
(0.684–0.724)
 < 0.001  < 0.001
 External validation 2 0.712
(0.688–0.735)
0.736
(0.714–0.758)
0.726
(0.703–0.749)
 < 0.001  < 0.001
  1. SOFA Sequential organ failure assessment, AUROC Area under the receiver operating characteristic
  2. aOriginal vs. modified model
  3. bOriginal vs. vasopressor only model