Fig. 7

Antibody parameters correlated with functional activity. Antibodies against CSP opsonise sporozoites and interact with FcγRs to promote phagocytosis, which is predominantly mediated by neutrophils. Rate ratios are shown for the relationship between IgG subclasses and IgG to NANP-repeat and C-terminal domains of CSP, and antibody functional activities (FcγRIIa or III-binding and neutrophil phagocytosis). Rate ratios are also shown for the relationship between FcγRIIa and FcγRIII binding and neutrophil phagocytosis. Values are rate ratios and represent the percent change in participants’ antibody functional activities for each unit increase in IgG reactivity or FcγR binding. p≤0.001 for all rate ratios except neutrophil phagocytosis with IgG3 (p=0.023) and IgG to NANP (p=0.023). See Additional file 1: Tables S4 to S11 for details. Figure created with BioRender.