Fig. 3

Protein-protein interaction network identified in neutrophils. A Protein-protein interaction network and top MCODE module clusters for DEGs in neutrophils of AD. The bottom shows the top enriched biological processes for each module. Circle and square indicate the up and downregulated genes of neutrophils in AD compared with NC. Node size represents the degree. Genes associated with AD are highlighted with a black border. B The enrichment of each module cluster in AD-associated gene lists, where the black border represents significant enrichment. Color and size of node indicate the significance and odds ratio of enrichment, respectively. C The Venn diagram shows the overlap of DEGs in neutrophils of AD versus NC across four blood transcriptomic datasets. D, E Heatmap of top enriched biological process terms’ parents of DEGs in AD (D) and MCI (E) across four datasets, colored by P-values