Table 1 Baseline characteristics of women with PCOS and age-matched controls
Primary analysis | ||
|---|---|---|
Variables | Deliveries of women with PCOS* | Age-matched deliveries of women without PCOS |
All | (n = 27,586) | (n = 110,344) |
Age at delivery [mean (SD)] | 30.86 (5.38) | 30.85 (5.33) |
Age at delivery [median (IQR)] | 30.00 (26.00–34.00) | 31.00 (27.00–34.00) |
Age categories, n(%) | ||
14–19 years | 467 (1.69) | 1802 (1.63) |
20–29 years | 11,537 (41.82) | 45,596 (41.32) |
30–39 years | 14,357 (52.04) | 58,313 (52.85) |
40–50 years | 1225 (4.44) | 4633 (4.20) |
Pre-gravid BMI [mean (SD)] | 26.54 (6.38) | 25.11 (5.43) |
Pre-gravid BMI [median (IQR)] | 24.00 (21.00–30.00) | 23.00 (21.00–27.00) |
BMI categories, n(%) | ||
< 25 kg/m2 | 13,055 (47.32) | 59,799 (54.19) |
25–29.9 kg/m2 | 6493 (23.54) | 25,103 (22.75) |
30–34.9 kg/m2 | 3667 (13.29) | 10,423 (9.45) |
35–39.9 kg/m2 | 1882 (6.82) | 4023 (3.65) |
≥ 40 kg/m2 | 1013 (3.67) | 2002 (1.81) |
Missing | 1476 (5.35) | 8994 (8.15) |
IMD, n(%) | ||
1 (most deprived) | 3334 (12.09) | 12,989 (11.77) |
2 | 2795 (10.13) | 11,052 (10.02) |
3 | 2706 (9.81) | 11,215 (10.16) |
4 | 2637 (9.56) | 11,031 (10.00) |
5 | 2973 (10.78) | 11,782 (10.68) |
6 | 2578 (9.35) | 10,165 (9.21) |
7 | 2547 (9.23) | 10,557 (9.57) |
8 | 2696 (9.77) | 10,319 (9.35) |
9 | 2693 (9.76) | 10,353 (9.38) |
10 (least deprived) | 2607 (9.45) | 10,793 (9.78) |
Missing | 19 (0.07) | 81 (0.07) |
Ethnicity, n(%) | ||
White | 13,343 (48.37) | 50,894 (46.12) |
South Asian | 1465 (5.31) | 3638 (3.30) |
Black Afro-Caribbean | 1567 (5.68) | 5315 (4.82) |
Mixed or multiple ethnicity | 170 (0.62) | 651 (0.59) |
Others | 721 (2.61) | 2561 (2.32) |
Missing | 10,320 (37.41) | 47,285 (42.85) |
Record of symptoms and measurements at baseline, n(%) | ||
PCO | 12,706 (46.06) | 0 (0) |
Hair loss | 2898 (10.51) | 2645 (2.40) |
Hirsutism | 1825 (6.62) | 645 (0.58) |
Anovulation | 17,852 (64.71) | 10,845 (9.83) |
High testosterone (serum testosterone level ≥ 2.0 nmol/L) | 3250 (11.78) | 467 (0.42) |
Other comorbidities, n(%) | ||
Type 2 diabetes | 675 (2.45) | 1259 (1.14) |
Prediabetes | 1123 (4.07) | 2038 (1.85) |
Hypertension | 489 (1.77) | 1230 (1.11) |
Thyroid disorders | 1105 (4.01) | 2403 (2.18) |
Number of babies at the delivery,n(%) | ||
1 | 27,163 (98.47) | 108,446 (98.28) |
2 | 409 (1.48) | 1864 (1.69) |
3 | 14 (0.05) | 30 (0.03) |
4 | 0 (0) | 4 (0.00) |