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Fig. 1 | BMC Medicine

Fig. 1

From: Dapagliflozin attenuates diabetes-induced diastolic dysfunction and cardiac fibrosis by regulating SGK1 signaling

Fig. 1

Reduction of fibrosis by dapagliflozin and morphologic changes by histological analysis. A Myocardial tissue was stained with Masson’s trichrome. B Collagen fiber deposition of the plaques is represented using Sirius Red staining. Sirius Red percentage for myocardial tissue in each group. CF The plaques were shown using immunohistochemistry staining of α-SMA, Fibronectin, TGF-β1, and 3-nitrotyrosine. G, H The expression of SGLT1 and SGLT2 and direct effects of dapagliflozin on immunohistochemistry analysis in myocardial tissue. Scale bar = 200μm. I RT-PCR analyses of indicated genes in myocardial tissue. J Western blot analyses of indicated genes in myocardial tissue (n = 4 per group). K Real-time PCR expressions of SGLT1 and SGLT2 in myocardial tissue. Values are means ± SEM (n = 10 per group). *p < 0.05, **p < 0.01, ***p < 0.001 compared to control group, p < 0.05, ††p < 0.01, †††p < 0.001 compared to diabetes group

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