Fig. 4

Sub-populations of EMT-featured secretory cells. A Heatmap and hierarchical clustering of 126 cells expressed EMT signature. B The branched trajectory of secretory cell status transition in a two-dimensional state-space inferred by Monocle 2 in all samples. Each dot corresponds to one single cell, colored according to cell types. C Visualization of the RNA velocity analysis results on the tSNE plot of the tubal secretory cells. D Volcano plot illustrating differential gene expression between EMT-high and EMT-low cells with red dots representing upregulated while blue dots for downregulated genes. FDR q values were estimated using the Benjamini-Hochberg procedure