Fig. 1

Flowchart illustrating criteria for selection of samples as well as the four analyses performed in the current study. Using data from over 40,000 participants, we start by establishing how grip strength relates to a total of 30 mental health-related behavioral phenotypes. Based on longitudinal data, we further determine the directionality of these associations. We then investigate how grip strength is related to regional GMV and examine whether GMV mediates any associations between grip strength and mental health outcomes